MRC Workshop on Dose-Finding Methodology in Early Phase Clinical Trials

22-24 March 2010, University of Reading

The workshop will provide an intensive programme of talks from world experts on current trends in this research field, together with small-group discussions, where open problems can be addressed and progress made. Participants will be able to learn about state-of-the-art adaptive designs for early phase clinical trials and related ethical issues, exchange research ideas, establish collaborative research links and discuss how to implement the methodology in practice. The workshop is supported by the Medical Research Council.

Keynote Speakers

Professor A.P. Grieve (U.K.), Professor J. O'Quigley (France), Professor J.R. Whitehead (U.K.)

Other Speakers

Professor D. Ashby (U.K.), Dr. D. Austin (U.K.), Dr. N. Benda (Germany), Professor K. Cheung (U.S.A.), Mr. R. Hemmings (U.K.), Dr. A. Iasonos (U.S.A.), Professor A. Ivanova (U.S.A.), Professor B. Jones (U.K.), Dr. A. Mander (U.K.), Dr. F. Miller (Sweden), Dr. H. Siedentop (Germany), Dr. F. Vandenhende (Belgium), Dr. S. Zohar (France)

Topics to be Covered

Bayesian Adaptive Designs for Early Phase Clinical Trials, Case Studies in Early Phase Clinical Trials, Decision-Theoretic Approaches, Dose-Titration Experiments, Designs for Bivariate Endpoints, Regulatory Issues, Up-and-Down Designs

A preliminary programme is available here.


In order to attend the workshop, the registration form should be completed and the appropriate fee paid. The deadline for receipt of these is 15 February 2010. The registration fee includes lunch and refreshments. At the time of registration, each participant will also receive a booklet containing the slides for all of the speakers' talks. For non-speakers, there will be a fee of £50 per day for academics and participants in the public sector, and a fee of £60 per day for those in industry. The fee for students is £20 per day. The current list of participants is available here.

The registration form is available both as a Word document and as a pdf file.

Poster/Software Demonstration Sessions

In addition to the invited sessions, there will be a poster/software demonstration session on the first day in which participants will be able to present a poster based on their research work or give a software demonstration.

Directions and Venue

The workshop will be held at the University of Reading on the Whiteknights campus. Directions on how to get to Reading are available here. The talks will take place in room G74 of the Philip Lyle Building, which is number 32 on this map of the Whiteknights campus and located off the Pepper Lane entrance. Since there is limited parking on campus, anyone who needs a parking place should contact Dr. Y. Zhou to obtain a permit.


Non-speakers who are planning to stay overnight in Reading should make their own arrangements for accommodation. There are a large number of hotels and guest houses in the area. A list issued by the Accommodation Service at the University of Reading and grouped by price bracket is available here.


The workshop is being organised by Dr. Y. Zhou at the University of Reading and Dr. D.S. Coad at Queen Mary, University of London. Their e-mail addresses are and